Police said the 12.10am accident happened at the intersection in front of Tesco Lotus Hang Dong shopping mall on Chiang Mai-Hod road in Tambon Mae Hia.
The two women in the car were killed. They were identified as the driver Patcharin Boonruang, 26, and Supaporn Promsuwan, 39.
The pickup driver has yet to be identified. He was severely injured and rushed to a nearby hospital.
Police have yet to investigate the cause of the accident. They think one of the two vehicles may have violated the red light signal at the intersection.