Kusoldarm rescue workers arrived at the scene at Thepkrasattri Road, northbound lane, near the SuperCheap store in Rassada.
The four people injured include the driver of the white pickup, 28-year-old Kittithorn Meejor, who has sustained injuries to his brow, 24-year-old passenger Manop Krongyod, who had arm and neck injuries, 21-year-old Apidet Insum and 17-year-old Punyawat Imsombat, who were both scratched.
A video shows a white pickup travelling at high speed, swerving to avoid hitting a car in front and then careering off the road into show houses along the side of the road.
All were taken to Vachira Phuket Hospital.